Search results for " CD18"

showing 3 items of 3 documents

A novel B cell population revealed by a CD38/CD24 gating strategy: CD38−CD24− B cells in centenarian offspring and elderly people

2012

The B cell arm of adaptive immunity undergoes significant modifications with age. Elderly people are characterized by impaired B cell responses reflected in a reduced ability to effectively respond against viruses and bacteria. Alterations of immunity with advancing age (immunosenescence) have been widely studied in centenarians who are considered a good example of successful aging. In recent years, attention has shifted to centenarian offspring (CO) as a model of people genetically advantaged for healthy aging and longevity. Here, we describe the preliminary characterization of a proposed new population of memory B cells, defined as CD19(+)CD38(-)CD24(-), which we find at higher frequencie…

AdultMaleParentsAgingCD180OffspringImmunosenescencePopulationB cell; CD38; CD24; CD180; Immunosenescence; Centenarian offspringLongevityCentenarian offspringCD38Lymphocyte ActivationCD19Article03 medical and health sciences0302 clinical medicineReference ValuesmedicineHumanseducationCD24B cell030304 developmental biologyAgedSettore MED/04 - Patologia GeneraleAged 80 and over0303 health scienceseducation.field_of_studyB cellB-LymphocytesImmunity CellularbiologyCD24 AntigenGeneral MedicineImmunosenescenceMiddle AgedAcquired immune systemADP-ribosyl Cyclase 13. Good healthmedicine.anatomical_structureImmunologybiology.proteinCytokinesFemaleGeriatrics and GerontologyCentenarianCD38030215 immunology
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The C-terminal rod 2 fragment of filamin A forms a compact structure that can be extended

2012

Filamins are large proteins that cross-link actin filaments and connect to other cellular components. The C-terminal rod 2 region of FLNa (filamin A) mediates dimerization and interacts with several transmembrane receptors and intracellular signalling adaptors. SAXS (small-angle X-ray scattering) experiments were used to make a model of a six immunoglobulin-like domain fragment of the FLNa rod 2 (domains 16–21). This fragment had a surprising three-branched structural arrangement, where each branch was made of a tightly packed two-domain pair. Peptides derived from transmembrane receptors and intracellular signalling proteins induced a more open structure of the six domain fragment. Mutagen…

Models Moleculargenetics [Receptors Dopamine D3]metabolism [Recombinant Proteins]Protein Conformationgenetics [Antigens CD18]chemistry [Recombinant Proteins]Plasma protein bindingCrystallography X-RayLigandsFilaminmetabolism [Antigens CD18]metabolism [Cytoskeletal Proteins]BiochemistryfilaminsContractile ProteinsProtein structuremetabolism [Peptide Fragments]FLNAchemistry [Antigens CD18]genetics [Cell Adhesion Molecules]Small-angle X-ray scatteringMicrofilament Proteinsgenetics [Contractile Proteins]Recombinant Proteinschemistry [Receptors Dopamine D3]FBLIM1 protein humanddc:540Domain (ring theory)DimerizationProtein Bindingchemistry [Contractile Proteins]FilaminsAntigens CD18metabolism [Cell Adhesion Molecules]BiologyScattering Small Anglemetabolism [Receptors Dopamine D3]Humanschemistry [Microfilament Proteins]Protein Interaction Domains and Motifsmetabolism [Mutant Proteins]DRD3 protein humanMolecular Biologymetabolism [Contractile Proteins]Actingenetics [Cytoskeletal Proteins]Cryoelectron MicroscopyMutagenesista1182Receptors Dopamine D3metabolism [Microfilament Proteins]Cell Biologychemistry [Cell Adhesion Molecules]genetics [Peptide Fragments]Peptide FragmentsCytoskeletal ProteinsCrystallographychemistry [Mutant Proteins]chemistry [Peptide Fragments]CD18 AntigensBiophysicschemistry [Cytoskeletal Proteins]Mutant Proteinsgenetics [Microfilament Proteins]Cell Adhesion MoleculesBiochemical Journal
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Down regulation of CD11b and CD18 expression in children with hypercholesterolemia: A preliminary report.

2009

BACKGROUND AND AIM: Cell adhesion molecules play an important role in the development of atherosclerosis mediating the attachment of monocytes to the endothelium. The aim of our study was to assess the cell surface expression of CD11b/CD18 integrin on the phagocytes of children affected by hypercholesterolemia. METHODS AND RESULTS: Twenty-six children with hypercholesterolemia (15 males, mean age 8.3, range 2-18) with a family history of early cardiovascular disease, as well as 26 children with normocholesterolemia matched for gender and age (15 males, mean age 8.3) were studied. Cell surface expression of CD11b/CD18 on peripheral blood mononuclear cells (PBMC) were analyzed by flow cytomet…

MaleSettore MED/09 - Medicina InternaAdolescentEndotheliumEndocrinology Diabetes and MetabolismDown-RegulationMedicine (miscellaneous)Pilot ProjectsCD18Context (language use)Peripheral blood mononuclear cellFlow cytometrychildrencd11b/cd18HumansMedicineFamily historyChildCD18PhagocytesCD11b AntigenNutrition and Dieteticsatherosclerosis; cd11b; cd11b/cd18; cd18; children; hypercholesterolemiahypercholesterolemiamedicine.diagnostic_testbiologybusiness.industryCell adhesion moleculeCD11bLipidsCross-Sectional Studiesmedicine.anatomical_structureIntegrin alpha MCD18 AntigensCase-Control StudiesChild PreschoolImmunologybiology.proteinFemaleatherosclerosisCardiology and Cardiovascular Medicinebusiness
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